Water → HCID 178509491, compound

HRID 842710Notes

Reaction equation

HRID 842710 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[N:6][C:7]([CH2:11][N:12]=[N+]=[N-])=[CH:8][CH:9]=2)[NH:4][N:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O>C1COCC1>[NH2:1][C:2]1[C:10]2[C:5](=[N:6][C:7]([CH2:11][NH2:12])=[CH:8][CH:9]=2)[NH:4][N:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 11776TriphenylphosphineHCID 178514547HCID 178514547, compound

Product 1

HCID 178509491HCID 178509491, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 3-amino-6-azidomethyl-7-azaindazole (60 mg, 0.317 mmol), triphenylphosphine (416 mg, 1.59 mmol) and water (86 mg, 4.76 mmol) in THF (10 mL) was stirred for 64 h. The solvent was evaporated in vacuo and the residue was purified by chromatography on silica (chloroform/ammonia, methanol gradient, 5-10% methanol) to give the title compound as a yellow solid:

Workup

  1. customThe solvent was evaporated in vacuo
  2. customthe residue was purified by chromatography on silica (chloroform/ammonia, methanol gradient, 5-10% methanol)

Sources & evidence

ORD record
ord-ee08a80d2e0b4893b2f2a0d0708dda4c
Source dataset
uspto-grants-2002_04
Patent number
US06376499B1

Reaction notes

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