反应详情

温度

60 °C

A solution of 2-bromophenol (5.89 g, 34.0 mmol) and 2,2,2-trifluoroethyliodide (16.8 g, 80.0 mmol) in DMF (60 mL) was treated with potassium carbonate (24.1 g, 174 mmol) at room temperature. The resulting mixture was heated in an oil bath (60° C., 2 d). The solvent was removed in vacuo and the residue dissolved in ether and water. The aqueous layer was extracted with two additional portions of ether and the combined organic extracts were washed with three portions of 1M NaOH solution and dried over Na2SO4. The solvent was removed in vacuo to afford the title compound (50).

1. customThe solvent was removed in vacuo
2. dissolutionthe residue dissolved in ether
3. extractionThe aqueous layer was extracted with two additional portions of ether
4. washthe combined organic extracts were washed with three portions of 1M NaOH solution
5. dry with materialdried over Na2SO4
6. customThe solvent was removed in vacuo