Water → HCID 14774175, compound

HRID 842820Notes

Reaction equation

HRID 842820 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6].C(N(CC)CC)C.[N:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][C:18]=1[CH2:27][O:28][C:29]1[CH:30]=[C:31]([CH:35]=[CH:36][CH:37]=1)[C:32](Cl)=[O:33].O>C(Cl)(Cl)Cl>[N:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][C:18]=1[CH2:27][O:28][C:29]1[CH:30]=[C:31]([CH:35]=[CH:36][CH:37]=1)[C:32]([NH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6])=[O:33]

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 167023-AminobenzonitrileHCID 14774174HCID 14774174, compound

Product 1

HCID 14774175HCID 14774175, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

A solution of 3-aminobenzonitrile (10 mmol) in 50 ml of chloroform and triethylamine (11 mmol) is added to a solution of 10 mmol of 3-(2-quinolinylmethyloxy)benzoic acid chloride in 20 ml of chloroform over a period of 10 minutes. The reaction is stirred at room temperature for 2 hours and is poured into water and then extracted into chloroform. The organic solution is dried and evaporated to give 3-(3-(2-quinolinylmethyloxy)benzoylamino)benzonitrile.

Workup

  1. extractionextracted into chloroform
  2. customThe organic solution is dried
  3. customevaporated

Sources & evidence

ORD record
ord-82a6213f76cb4ac5a3199646e7802cf6
Source dataset
uspto-grants-2002_04
Patent number
US06376512B1

Reaction notes

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