反应详情

(S)-malic acid was dissolved in isopropanol and p-toluenesulphonic acid (cat) was added and stirred at room temperature for 24 h. The reaction mixture was concentrated and distilled to give (S)-diisopropyl malate as colorless liquid. The residual material in the distillation flask was dissolved in EtOH and processed as above. Distillation afforded additional diester, raising the total yield.

1. concentrationThe reaction mixture was concentrated
2. distillationdistilled