Water → HCID 22617174, compound

HRID 843366Notes

Reaction equation

HRID 843366 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]=[C:14](Cl)[C:15]([F:18])([F:17])[F:16].[CH2:20]([NH:23][CH2:24][CH2:25][CH3:26])[CH2:21][CH3:22].C(N(CC)CC)C.O>CN(C)C=O>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]=[C:14]([N:23]([CH2:24][CH2:25][CH3:26])[CH2:20][CH2:21][CH3:22])[C:15]([F:18])([F:17])[F:16]

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 8902DipropylamineHCID 22617159HCID 22617159, compound

Product 1

HCID 22617174HCID 22617174, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

First, 0.17 g (0.50 mmol) of N-(2,6-dichloro-4-trifluoromethylphenyl)-2,2,2-trifluoroacetoimidoyl chloride was dissolved in 10 ml of N,N-dimethyl formamide, to which 0.10 g (0.50 mmol) of dipropylamine and 0.10 g (0.50 mmol) of triethylamine were added, and the mixture was stirred at room temperature for 3 hours. Water was poured into the reaction mixture, which was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure to give 0.18 g of N′-(2,6-dichloro-4-trifluoromethylphenyl)-2,2,2-trifluoro-N,N-dipropylacetamidine (hereinafter referred to as present compound 56).

Workup

  1. additionwere added
  2. extractionwas extracted with ethyl acetate
  3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-6d445552ce41455bbe554b8532fd1aa0
Source dataset
uspto-grants-2002_04
Patent number
US06376710B2

Reaction notes

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