Hydrochloric Acid → HCID 9872862, compound

HRID 843438Notes

Reaction equation

HRID 843438 reaction equation
Cl.C(OC([N:9]1[CH2:14][C@H:13]([O:15][CH2:16][C:17]2[CH:26]=[C:25]([O:27][CH3:28])[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=2)[C@@H:12]([C:29]2[CH:34]=[CH:33][C:32]([O:35][CH2:36][CH2:37][CH2:38][O:39][CH2:40][C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=3[O:47][CH3:48])=[CH:31][CH:30]=2)[C@H:11]([CH2:49][OH:50])[CH2:10]1)=O)(C)(C)C>CO>[CH3:48][O:47][C:42]1[CH:43]=[CH:44][CH:45]=[CH:46][C:41]=1[CH2:40][O:39][CH2:38][CH2:37][CH2:36][O:35][C:32]1[CH:31]=[CH:30][C:29]([C@@H:12]2[C@@H:13]([O:15][CH2:16][C:17]3[CH:26]=[C:25]([O:27][CH3:28])[C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH:18]=3)[CH2:14][NH:9][CH2:10][C@H:11]2[CH2:49][OH:50])=[CH:34][CH:33]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57261710HCID 57261710, compound

Product 1

HCID 9872862HCID 9872862, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In an analogous manner to that described in Example 13 (j) by cleavage of the BOC group using a solution of hydrogen chloride in methanol, starting from (3S,4R,5R)-3-hydroxymethyl-4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-5-(4-methoxy-naphthalen-2-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester [Example 13 (h)] there was obtained (3S,4R,5R)-[4-[4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl]-5-(4-methoxy-naphthalen-2-ylmethoxy)-piperidin-3-yl]-methanol as a colorless foam; MS: 572 (M+H)+.

Sources & evidence

ORD record
ord-c8d68af987f64af4b5c340c5a40d4ec9
Source dataset
uspto-grants-2002_04
Patent number
US06376672B1

Reaction notes

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