Hydrochloric Acid → HCID 18734737, compound

HRID 843715Notes

Reaction equation

HRID 843715 reaction equation
[N:1]([CH2:4][C@H:5]([NH:11]C(OC(C)(C)C)=O)[C:6]([O:8][CH2:9][CH3:10])=[O:7])=[N+:2]=[N-:3].[ClH:19]>C(OCC)(=O)C>[ClH:19].[NH2:11][C@@H:5]([CH2:4][N:1]=[N+:2]=[N-:3])[C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18734739HCID 18734739, compound

Product 1

HCID 18734737HCID 18734737, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of ethyl 3-azido-2(S)-(tert-butoxycarbonylamino)propionate (0.5 g) in ethyl acetate (5 ml) was added 4N HCl in ethyl acetate (5 ml) at 0° C. After stirring at room temperature for 2 hours, the mixture was evaporated in vacuo. The residue was recrystallized from diethyl ether to give ethyl 2(S)-amino-3-azidopropionate hydrochloride (0.3 g).

Workup

  1. customthe mixture was evaporated in vacuo
  2. customThe residue was recrystallized from diethyl ether

Sources & evidence

ORD record
ord-e0de9e0b5c4d4cb180f536711c718717
Source dataset
uspto-grants-2002_04
Patent number
US06380215B1

Reaction notes

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