Hydrochloric Acid → HCID 86584070, compound

HRID 843736Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:44])[C@@H:5]([NH:36]C(OC(C)(C)C)=O)[CH2:6][NH:7][C:8]([C@@H:10]1[CH2:15][CH2:14][CH2:13][N:12]([C:16](=[O:35])[CH2:17][CH2:18][CH:19]2[CH2:24][CH2:23][N:22]([C:25]([O:27][CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[O:26])[CH2:21][CH2:20]2)[CH2:11]1)=[O:9])[CH3:2].[ClH:45]>C(OCC)(=O)C>[ClH:45].[CH2:1]([O:3][C:4](=[O:44])[C@@H:5]([NH2:36])[CH2:6][NH:7][C:8]([C@@H:10]1[CH2:15][CH2:14][CH2:13][N:12]([C:16](=[O:35])[CH2:17][CH2:18][CH:19]2[CH2:20][CH2:21][N:22]([C:25]([O:27][CH2:28][C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)=[O:26])[CH2:23][CH2:24]2)[CH2:11]1)=[O:9])[CH3:2]

Participants

Conditions

Temperature: 0 °C

Procedure

To a solution of N-[(R)-1-{3-(1-benzyloxycarbonyl-4-piperidyl)propionyl}-3-piperidylcarbonyl]-2(S)-(tert-butoxycarbonyl)amino-β-alanine ethyl ester (5.98 g) in ethyl acetate (60 ml) was added a solution of 4N HCl in ethyl acetate (24.2 ml) under stirring at 0° C. After stirring at ambient temperature for 2 hours, the resulting precipitates were collected by filtration to give N-[(R)-1-{3-(1-benzyloxycarbonyl-4-piperidyl)propionyl}-3-piperidylcarbonyl]-2(S)-amino-β-alanine ethyl ester hydrochloride (3.41 g).

Workup

stirringAfter stirring at ambient temperature for 2 hours
customthe resulting precipitates
filtrationwere collected by filtration

Sources & evidence

ORD record: ord-f86dd4af73ba48e282c7d40ac596092c
Source dataset: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06380215B1

Reaction notes

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