Hydrochloric Acid → HCID 22611921, compound

HRID 843745Notes

Reaction equation

HRID 843745 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([O:17][CH2:18][C:19]([N:21]2[CH2:26][CH2:25][CH2:24][CH:23]([C:27]([NH:29][CH2:30][CH2:31][C:32]([OH:34])=[O:33])=[O:28])[CH2:22]2)=[O:20])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1.[ClH:35]>[Pd].O1CCCC1>[ClH:35].[NH:11]1[CH2:16][CH2:15][CH:14]([O:17][CH2:18][C:19]([N:21]2[CH2:26][CH2:25][CH2:24][CH:23]([C:27]([NH:29][CH2:30][CH2:31][C:32]([OH:34])=[O:33])=[O:28])[CH2:22]2)=[O:20])[CH2:13][CH2:12]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22611864HCID 22611864, compound

Product 1

HCID 22611921HCID 22611921, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of N-[1-{2-(1-benzyloxycarbonyl-4-piperidyloxy)acetyl}-3-piperidylcarbonyl]-β-alanine (1.16 g) and 10% Pd—C (0.23 g, 50% wet) in a solution of 1N HCl (2.44 ml) and tetrahydrofuran (20 ml) was hydrogenated at atmospheric pressure for 2 hours. After the catalyst was removed by filtration, the filtrate was concentrated in vacuo and freeze-dried to give N-[1-{2-(4-piperidyloxy)acetyl}-3-piperidylcarbonyl]-β-alanine hydrochloride (0.69 g).

Workup

  1. customAfter the catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated in vacuo
  3. customfreeze-dried

Sources & evidence

ORD record
ord-fdb46281ffeb4390bc7433fd5e809f7a
Source dataset
uspto-grants-2002_04
Patent number
US06380215B1

Reaction notes

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