Hydrochloric Acid → HCID 9907670, compound

HRID 843746Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][C:16]([N:18]2[CH2:23][CH2:22][CH2:21][CH:20]([C:24]([NH:26][CH2:27][CH2:28][C:29]([OH:31])=[O:30])=[O:25])[CH2:19]2)=[O:17])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:32]>C(OCC)(=O)C>[ClH:32].[NH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][CH2:15][C:16]([N:18]2[CH2:23][CH2:22][CH2:21][CH:20]([C:24]([NH:26][CH2:27][CH2:28][C:29]([OH:31])=[O:30])=[O:25])[CH2:19]2)=[O:17])[CH2:12][CH2:13]1

Participants

Conditions

Temperature: 0 °C

Procedure

A solution of N-[1-{3-(1-tert-butoxycarbonyl-4-piperidyl)propionyl}-3-piperidylcarbonyl]-β-alanine (1.58 g) in ethyl acetate (16 ml) was added 4N HCl in ethyl acetate (13.5 ml) under stirring at 0° C. After stirring at ambient temperature for 2 hours, resulting precipitate was collected by filtration to give N-[1-{3-(4-piperidyl)-propionyl}-3-piperidylcarbonyl]-β-alanine hydrochloride (1.27 g).

Workup

stirringAfter stirring at ambient temperature for 2 hours
customresulting precipitate
filtrationwas collected by filtration

Sources & evidence

ORD record: ord-8391edfa9b1e491b92adbc9cf102b31f
Source dataset: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06380215B1

Reaction notes

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