反应详情

The sulfone from Step F (1.20 g, 4.21 mmol) was dissolved in ethyl acetate (10 mL). The solution was saturated with hydrogen chloride gas and stirred for 1 hour, then concentrated in vacuo. The residue was partitioned between methylene chloride (10 mL) and water (10 mL). The layers were separated and the aqueous layer was washed with methylene chloride (3×10 mL) and concentrated in vacuo to provide the title compound as a white solid which was sufficiently pure for use in the next step.

1. concentrationconcentrated in vacuo
2. customThe residue was partitioned between methylene chloride (10 mL) and water (10 mL)
3. customThe layers were separated
4. washthe aqueous layer was washed with methylene chloride (3×10 mL)
5. concentrationconcentrated in vacuo