反应详情

10.32 g of 2-indolecarboxylic acid in 70 ml of THF are placed in a three-necked flask at RT, 10.38 g of carbonyldiimidazole are added and, after the evolution of gas has ceased, 7.62 g of benzyl alcohol are then added. After refluxing for 5 hours, the mixture is poured into water and extracted with DCM, and the extracts are dried and evaporated. The crystals formed are washed with iPrOH to give 13.62 g of the expected compound: m.p.=136° C.

1. temperatureAfter refluxing for 5 hours
2. extractionextracted with DCM
3. customthe extracts are dried
4. customevaporated
5. customThe crystals formed
6. washare washed with iPrOH