Potassium Carbonate → 1-(1-Ethoxycyclopropyl)-4-ethynyl-2-tert-butylbenzene

HRID 844746Notes

Reaction equation

HRID 844746 reaction equation
[CH2:1]([O:3][C:4]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]#[C:14][Si](CC)(CC)CC)=[CH:9][C:8]=2[C:22]([CH3:25])([CH3:24])[CH3:23])[CH2:6][CH2:5]1)[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:1]([O:3][C:4]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]#[CH:14])=[CH:9][C:8]=2[C:22]([CH3:23])([CH3:25])[CH3:24])[CH2:6][CH2:5]1)[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22613276HCID 22613276, compound2×

Product 1

HCID 225688751-(1-Ethoxycyclopropyl)-4-ethynyl-2-tert-butylbenzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [4-(1-ethoxycyclopropyl)-3-tert-butyl-phenylethynyl]-triethylsilane (Intermediate 111, 215.0 mg, 0.69 mmol) in methanol (10 mL) was treated with potassium carbonate (80.0 mg, 0.58 mmol) and stirred overnight at ambient temperature. The crude alkyne, 169 mg, was used directly in the next reaction.

Sources & evidence

ORD record
ord-6fe2d0b7e25f42ce9bb95a6a4ea77bce
Source dataset
uspto-grants-2002_04
Patent number
US06380256B1

Reaction notes

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