Hydrazine hydrate (1:1) → HCID 20133456, compound

HRID 845061Notes

Reaction equation

HRID 845061 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8](=O)[CH2:7][CH2:6]2.O.[C:14]([OH:18])(=O)[CH:15]=O.O.[NH2:20][NH2:21]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8]1=[N:20][NH:21][C:14](=[O:18])[CH:15]=[C:7]1[CH2:6]2

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 787875-Methoxyindan-1-oneHCID 15620607Glyoxylic acid, monohydrate

Product 1

HCID 20133456HCID 20133456, compound

Procedure

By a method similar to that described in Preparation 3, treatment of 5-methoxy-1-indanone with glyoxylic acid hydrate and hydrazine hydrate gave 7-methoxy-[5H]-indeno-[1,2-c]pyridazin-3[2H]-one (m.p. 280°-4°, from concentrated hydrochloric acid); ν(Nujol mull) 3350-2200, 1680, 1610, 1580, 1259 and 1041 cm-1 ; δ(DMSO-d6) 2.80 (4H,s,5,6-H2), 3.73 (3H,s,CH3O), 6.74 (1H,s,4-H) 7.00 (1H, dd,8-H), 7.29 (1H,dd,9-H), 7.55 (1H,dd,10-H), 12.86 (1H,br,NH).

Sources & evidence

ORD record
ord-dd5b2538cedb4279b00e37183e2f97c2
Source dataset
uspto-grants-1988_07
Patent number
US04755511

Reaction notes

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