3-Mercaptopropionic Acid → HCID 14011802, compound

HRID 845079Notes

Reaction equation

HRID 845079 reaction equation
[SH:1][CH2:2][CH2:3][C:4]([OH:6])=[O:5].[Na].Br[CH2:9][CH2:10]Cl.[CH3:12][C:13]([C:16]1[CH:21]=[C:20]([SH:22])[CH:19]=[C:18]([C:23]([CH3:26])([CH3:25])[CH3:24])[C:17]=1[OH:27])([CH3:15])[CH3:14]>>[CH3:26][C:23]([C:18]1[CH:19]=[C:20]([S:22][CH2:9][CH2:10][S:1][CH2:2][CH2:3][C:4]([OH:6])=[O:5])[CH:21]=[C:16]([C:13]([CH3:15])([CH3:14])[CH3:12])[C:17]=1[OH:27])([CH3:24])[CH3:25]

Participants

5

Reactant 4

HCID 65143-Mercaptopropionic AcidHCID 78491-Bromo-2-ChloroethaneHCID 703702,6-Di-tert-butyl-4-mercaptophenolHCID 5360545Sodium

Product 1

HCID 14011802HCID 14011802, compound

Procedure

The title compound was prepared according to the method of Example 5 from 3-mercaptopropionic acid (6.1 g, 0.057 mole); sodium (3.9 g, 0.17 mole); 1-bromo-2-chloroethane (12.4 g, 0.086 mole); and 2,6-bis(1,1-dimethylethyl)-4-mercaptophenol (13.7 g, 0.057 mole), purified by chromatography on silica and recrystallized from ethyl acetate/hexane, m.p. ca. 57.5° C.

Workup

  1. customrecrystallized from ethyl acetate/hexane, m.p. ca. 57.5° C.

Sources & evidence

ORD record
ord-f7baf4ae14754803b6d2eb5e92d16eeb
Source dataset
uspto-grants-1988_07
Patent number
US04755524

Reaction notes

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