HCID 14208607, compound → HCID 14208608, compound

HRID 845186Notes

Reaction equation

HRID 845186 reaction equation
CC([NH:5][S:6]([C:9]1[CH:13]=[CH:12][S:11][C:10]=1[C:14]1[CH2:19][CH2:18][CH2:17][C:16](=[O:20])[CH:15]=1)(=[O:8])=[O:7])(C)C>FC(F)(F)C(O)=O>[O:20]=[C:16]1[CH2:17][CH2:18][CH2:19][C:14]([C:10]2[S:11][CH:12]=[CH:13][C:9]=2[S:6]([NH2:5])(=[O:8])=[O:7])=[CH:15]1

Participants

3

Reactant 1

HCID 14208607HCID 14208607, compound

Product 1

HCID 14208608HCID 14208608, compoundYield 58.1%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of the product from Example 1 (6.0 g, 0.0192 mole) in trifluoroacetic acid (20 mL) was stirred at room temperature overnight, was stripped to an oil, and crystallized with ethyl acetate/ether to yield 2.87 g solid, m.p. 140°-147° C.

Workup

  1. customcrystallized with ethyl acetate/ether

Sources & evidence

ORD record
ord-85db777048854489b51f7a2015fb3f38
Source dataset
uspto-grants-1988_07
Patent number
US04756742

Reaction notes

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