Hydrochloric Acid → HCID 131715628, compound

HRID 845199Notes

Reaction equation

HRID 845199 reaction equation
N[C@H](C(OC)=O)[C@H](CC)C.CC(C)(OC([NH:17][C@@H:18]([CH2:35][CH:36]([CH3:38])[CH3:37])[CH:19]([OH:34])[CH2:20][NH:21][C:22]([NH:24][C@H:25]([C:30]([O:32][CH3:33])=[O:31])[C@H:26]([CH2:28][CH3:29])[CH3:27])=[O:23])=O)C.[ClH:40]>O1CCOCC1>[ClH:40].[NH2:17][C@@H:18]([CH2:35][CH:36]([CH3:37])[CH3:38])[CH:19]([OH:34])[CH2:20][NH:21][C:22]([NH:24][C@H:25]([C:30]([O:32][CH3:33])=[O:31])[C@H:26]([CH2:28][CH3:29])[CH3:27])=[O:23]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 75735L-Isoleucine, methyl esterHCID 131715630HCID 131715630, compound

Product 1

HCID 131715628HCID 131715628, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The isoleucine, methyl ester product from part (d) (0.43 g., 1.03 mmole) is dissolved in a solution of hydrochloric acid in dioxane (2N, 3 ml.) and kept at room temperature for 2.5 hours. The mixture is then concentrated to dryness in vacuo to give N-[[[(3S)-3-amino-2-hydroxy-5-methylhexyl]amino]carbonyl]-L-isoleucine, methyl ester, monohydrochloride.

Workup

  1. concentrationThe mixture is then concentrated to dryness in vacuo

Sources & evidence

ORD record
ord-8d8d4beb60bd4bd3b2a1b8f7e712cdbc
Source dataset
uspto-grants-1988_07
Patent number
US04757050

Reaction notes

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