反应详情

5-Hydroxymethyl-4-methoxymethyl-beta-carboline-3-carboxylic acid ethyl ester (7.27 g) is refluxed in isopropanol (1000 ml) with titanium tetraisopropylate (7.1 ml) for 5 hours. The solution is evaporated, the residue is dissolved in ethyl acetate. The complete solution is reached by addition of 1N hydrochloric acid. Then it is made alkaline by addition of 1N sodium hydroxide solution. A precipitate resulting thereby is suctioned off. The filtrate is evaporated and yields a residue of 6.0 g of the title compound.

1. customThe solution is evaporated
2. dissolutionthe residue is dissolved in ethyl acetate
3. additionThe complete solution is reached by addition of 1N hydrochloric acid
4. additionby addition of 1N sodium hydroxide solution
5. customA precipitate resulting
6. customThe filtrate is evaporated