Hydrazine hydrate (1:1) → 1,4-Dihydro-2,6-dimethyl-3-ethoxycarbonyl-4-(3-nitrophenyl)-5-(2-aminoethoxy)carbonyl-pyridine

HRID 845259Notes

Reaction equation

HRID 845259 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([CH3:38])=[C:5]([C:22]([O:24][CH2:25][CH2:26][N:27]2C(=O)C3=CC=CC=C3C2=O)=[O:23])[CH:6]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-:21])=[O:20])[CH:14]=2)[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9].O.NN>>[CH3:1][C:2]1[NH:3][C:4]([CH3:38])=[C:5]([C:22]([O:24][CH2:25][CH2:26][NH2:27])=[O:23])[CH:6]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-:21])=[O:20])[CH:14]=2)[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 135634151,4-Dihydro-2,6-dimethyl-3-ethoxycarbonyl-4-(3-nitrophenyl)-5-(2-phthalimidoethoxy)carbonyl-pyridine

Product 1

HCID 135634161,4-Dihydro-2,6-dimethyl-3-ethoxycarbonyl-4-(3-nitrophenyl)-5-(2-aminoethoxy)carbonyl-pyridine

Procedure

Prepared by a method analogous to that of Example 1(b) from 20.78 g (40 mmol) of 1,4-dihydro-2,6-dimethyl-3-ethoxycarbonyl-4-(3-nitrophenyl)-5-(2-phthalimidoethoxy)carbonyl-pyridine and 5.83 ml (120 mmol) of hydrazine hydrate. 13.39 g (86%) of yellow crystals, melting point 137°-139° C.

Sources & evidence

ORD record
ord-902d9ee9c9744b72ba87e291680da56e
Source dataset
uspto-grants-1988_07
Patent number
US04757080

Reaction notes

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