Hydrazine hydrate (1:1) → HCID 20132514, compound

HRID 845261Notes

Reaction equation

[CH3:1][C:2]1[NH:3][C:4]([CH3:40])=[C:5]([C:24]([O:26][CH2:27][CH2:28][N:29]2C(=O)C3=CC=CC=C3C2=O)=[O:25])[CH:6]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[N+:21]([O-:23])=[O:22])[C:7]=1[C:8]([O:10][CH2:11][CH:12]([CH3:14])[CH3:13])=[O:9].O.NN>>[CH3:1][C:2]1[NH:3][C:4]([CH3:40])=[C:5]([C:24]([O:26][CH2:27][CH2:28][NH2:29])=[O:25])[CH:6]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[N+:21]([O-:23])=[O:22])[C:7]=1[C:8]([O:10][CH2:11][CH:12]([CH3:14])[CH3:13])=[O:9]

Participants

Reactant 2

HCID 24654Hydrazine hydrate (1:1)

HCID 14011674HCID 14011674, compound

Product 1

HCID 20132514HCID 20132514, compoundYield 96.5%

Procedure

Prepared by a method analogous to that of Example 1(b) from 10.94 g (20 mmol) of 1,4-dihydro-2,6-dimethyl-3-isobutoxycarbonyl-4-(2-nitrophenyl)-5-(2-phthalimidoethoxycarbonyl)-pyridine and 3.0 ml (60 mmol) of hydrazine hydrate. 8.06 g (96%) of a viscous yellow oil are obtained. This product is used for reactions without further purification.

Sources & evidence

ORD record: ord-65b79e3f06fd416da97dd6def90503e0
Source dataset: uspto-grants-1988_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04757080

Reaction notes

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