Methyl 3-aminocrotonate → HCID 13799834, compound

HRID 845262Notes

Reaction equation

HRID 845262 reaction equation
[C:1]1(=[O:34])[N:5]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13](=[O:28])[C:14](=[CH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([N+:25]([O-:27])=[O:26])[CH:20]=2)[C:15]([CH3:17])=O)[C:4](=[O:29])[C:3]2=[CH:30][CH:31]=[CH:32][CH:33]=[C:2]12.[CH3:35][O:36][C:37](=[O:42])/[CH:38]=[C:39](\[NH2:41])/[CH3:40]>C(O)(C)C>[CH3:40][C:39]1[NH:41][C:15]([CH3:17])=[C:14]([C:13]([O:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][N:5]2[C:1](=[O:34])[C:2]3=[CH:33][CH:32]=[CH:31][CH:30]=[C:3]3[C:4]2=[O:29])=[O:28])[CH:18]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([N+:25]([O-:27])=[O:26])[CH:20]=2)[C:38]=1[C:37]([O:36][CH3:35])=[O:42]

Participants

4

Reactant 2

HCID 643918Methyl 3-aminocrotonateHCID 54551076HCID 54551076, compound

Product 1

HCID 13799834HCID 13799834, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

12.0 g (26 mmol) of 2-(3-nitrobenzylidene)-acetoacetic acid-(6-phthalimidohexyl)ester and 3.0 g (26 mmol) of 3-amino-crotonic acid methyl ester are boiled under reflux in 100 ml of isopropanol for 4 hours. After removal of the solvent by evaporation under vacuum, 15.0 g of a brownish yellow oil suitable for reactions without further purification are obtained.

Workup

  1. customAfter removal of the solvent
  2. customby evaporation under vacuum, 15.0 g of a brownish yellow oil suitable for reactions
  3. customwithout further purification
  4. customare obtained

Sources & evidence

ORD record
ord-807b94f5530146beb48d2ab9a5261385
Source dataset
uspto-grants-1988_07
Patent number
US04757080

Reaction notes

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