Hydrazine hydrate (1:1) → HCID 13563418, compound

HRID 845274Notes

Reaction equation

HRID 845274 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([CH3:43])=[C:5]([C:21]([O:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][N:32]2C(=O)C3=CC=CC=C3C2=O)=[O:22])[CH:6]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=2)[C:7]=1[C:8]([O:10][CH3:11])=[O:9].O.NN>COC(C)(C)C>[CH3:1][C:2]1[NH:3][C:4]([CH3:43])=[C:5]([C:21]([O:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][NH2:32])=[O:22])[CH:6]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=2)[C:7]=1[C:8]([O:10][CH3:11])=[O:9]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13752662HCID 13752662, compound

Product 1

HCID 13563418HCID 13563418, compoundYield 78.2%

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

Prepared by a method analogous to that of Example 1(b) from 6.75 g (11.5 mmol) of 1,4-dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-5-(8-phthalimidooctyloxy)carbonyl-pyridine and 1.7 ml (34.5 mmol) of hydrazine hydrate. 4.13 g (78%) of yellow crystals melting at 129°-131° C. obtained with tert.-butyl methyl ether.

Sources & evidence

ORD record
ord-95baf227307c48e2875cab389643a532
Source dataset
uspto-grants-1988_07
Patent number
US04757080

Reaction notes

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