反应详情

A suspension of 4-hydroxyacetophenone (27.2 g, 0.2 mole), 1-bromobutane (41.8 g, 0.305 mole) and potassium carbonate (41.4 g, 0.3 mole) in acetone (400 ml) were heated under reflux for 48 hours. Water (200 ml) was then added and the mixture extracted with ethyl acetate (300 ml) and washed with water (2×150 ml). The organic solution was dried and evaporated under reduced pressure to give an orange liquid which solidified on cooling to give the product (38.0 g, 99%) which was used in the next reaction without further purification.

1. temperaturewere heated
2. temperatureunder reflux for 48 hours
3. extractionthe mixture extracted with ethyl acetate (300 ml)
4. washwashed with water (2×150 ml)
5. customThe organic solution was dried
6. customevaporated under reduced pressure
7. customto give an orange liquid which
8. temperatureon cooling