Guaiacol → HCID 15219061, compound

HRID 845527Notes

Reaction equation

HRID 845527 reaction equation
Cl[CH:2]([F:4])[F:3].[C:5]1([O:12][CH3:13])[C:6](=[CH:8][CH:9]=[CH:10][CH:11]=1)[OH:7].[OH-].[Na+]>O.O1CCOCC1>[F:3][CH:2]([F:4])[O:7][C:6]1[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=1[O:12][CH3:13]

Participants

6

Reactant 3

HCID 460GuaiacolHCID 6372ChlorodifluoromethaneHCID 14798Sodium Hydroxide

Product 1

HCID 15219061HCID 15219061, compoundYield 73%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

About 58 g of chlorodifluoromethane are passed into a solution of 55.5 g of guaiacol and 130 g of sodium hydroxide in 300 ml of water and 300 ml of dioxane at 60° C. The mixture is filtered at 10° C. and the organic layer is separated off, dried with anhydrous potassium carbonate and distilled. 56 g (73%) of 1-difluoromethoxy-2-methoxybenzene of boiling point 75°-76° C./0.9 kPa are obtained.

Workup

  1. filtrationThe mixture is filtered at 10° C.
  2. customthe organic layer is separated off
  3. dry with materialdried with anhydrous potassium carbonate
  4. distillationdistilled

Sources & evidence

ORD record
ord-f0393391739f44e7891a3cf18ce3a955
Source dataset
uspto-grants-1988_07
Patent number
US04758579

Reaction notes

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