Ammonium Chloride → HCID 178513519, compound

HRID 84563Notes

Reaction equation

HRID 84563 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]([C:13]2[S:29][C:16]3[C:17]4[CH:25]=[CH:24][C:23]([C:26](O)=[O:27])=[CH:22][C:18]=4[O:19][CH2:20][CH2:21][C:15]=3[CH:14]=2)=[N:10][NH:11][CH:12]=1.[Cl-].[NH4+].C[N:33](C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]([C:13]2[S:29][C:16]3[C:17]4[CH:25]=[CH:24][C:23]([C:26]([NH2:33])=[O:27])=[CH:22][C:18]=4[O:19][CH2:20][CH2:21][C:15]=3[CH:14]=2)=[N:10][NH:11][CH:12]=1

Participants

6

Reactant 4

HCID 25517Ammonium ChlorideHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 178524099HCID 178524099, compound

Product 1

HCID 178513519HCID 178513519, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following Example 47, 2-(4-(2-chlorophenyl)-1H-pyrazol-3-yl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxylic acid and ammonium chloride were coupled with HATU and DIPEA in DMF to give 274.

Sources & evidence

ORD record
ord-2f1bb89079d140b6a3cfee96cdd524d3
Source dataset
uspto-grants-2014_09
Patent number
US08846762B2

Reaction notes

Loading…