Potassium Carbonate → HCID 13913533, compound

HRID 845745Notes

Reaction equation

HRID 845745 reaction equation
C([O:4][C:5]1[CH:40]=[CH:39][C:8]([CH2:9][N:10]2[C:20]3[C:15](=[CH:16][C:17]([N:21]4[CH2:26][CH2:25][N:24]([C:27](=[O:38])[C:28]5[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[C:30]([O:36][CH3:37])[CH:29]=5)[CH2:23][CH2:22]4)=[CH:18][CH:19]=3)[CH2:14][CH2:13][C:11]2=[O:12])=[CH:7][CH:6]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO.O>[OH:4][C:5]1[CH:40]=[CH:39][C:8]([CH2:9][N:10]2[C:20]3[C:15](=[CH:16][C:17]([N:21]4[CH2:22][CH2:23][N:24]([C:27](=[O:38])[C:28]5[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[C:30]([O:36][CH3:37])[CH:29]=5)[CH2:25][CH2:26]4)=[CH:18][CH:19]=3)[CH2:14][CH2:13][C:11]2=[O:12])=[CH:7][CH:6]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 13913532HCID 13913532, compound

Product 1

HCID 13913533HCID 13913533, compoundYield 51.5%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

1-(4-Acetoxybenzyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril (2 g) was dissolved in methanol (20 ml). To the solution was added a solution of potassium carbonate (1.53 g) in water (20 ml) and the mixture was stirred at room temperature for 30 minutes. After completion of reaction, the reaction mixture was poured into water and extracted with chloroform. The extract was washed with saturated saline solution, dried over magnesium sulfate and evaporated under reduced pressure. The residue was recrystallized from ethanol to give 1-(4-hydroxybenzyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril (950 mg).

Workup

  1. customAfter completion of reaction
  2. extractionextracted with chloroform
  3. washThe extract was washed with saturated saline solution
  4. dry with materialdried over magnesium sulfate
  5. customevaporated under reduced pressure
  6. customThe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-77aead2d00984884a51a39e387d74c4f
Source dataset
uspto-grants-1988_07
Patent number
US04760064

Reaction notes

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