Trifluoroacetic acid → HCID 22839130, compound

HRID 845845Notes

Reaction equation

HRID 845845 reaction equation
[C:1]([O:4][CH2:5][C:6]1[CH2:13][S:12][C@H:11]2[N:8]([C:9](=[O:28])[C@H:10]2[NH:14][C:15]2[S:16][C:17]([C:20](=[O:27])[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[CH:18][N:19]=2)[C:7]=1[C:29]([O:31]C(C1C=CC=CC=1)C1C=CC=CC=1)=[O:30])(=[O:3])[CH3:2].C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O>ClCCl>[C:1]([O:4][CH2:5][C:6]1[CH2:13][S:12][C@H:11]2[N:8]([C:9](=[O:28])[C@H:10]2[NH:14][C:15]2[S:16][C:17]([C:20](=[O:27])[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)=[CH:18][N:19]=2)[C:7]=1[C:29]([OH:31])=[O:30])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 86742287HCID 86742287, compound

Product 1

HCID 22839130HCID 22839130, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A 235 mg portion of (6R-trans)-3-[(Acetyloxy)methyl]7-[(5-benzoyl-2-thiazolyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, diphenylmethyl ester was reacted with anisole and trifluoroacetic acid in dichloromethane as described in Example 5, giving 143 mg of the desired product as a pale yellow powder.

Sources & evidence

ORD record
ord-9f19d0e09a96497b96f4c8c8396f2bfa
Source dataset
uspto-grants-1988_07
Patent number
US04760140

Reaction notes

Loading…