Sodium → HCID 19994231, compound

HRID 845904Notes

Reaction equation

HRID 845904 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH:18][C:19]([CH3:26])=[CH:20][C:21](OCC)=[O:22])=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[Na]>C(O)(C)C>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:21](=[O:22])[CH:20]=[C:19]([CH3:26])[NH:18][C:16]2=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 54173189HCID 54173189, compound

Product 1

HCID 19994231HCID 19994231, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

using isopropyl 2-chloro-4-fluoro-5-{3-[2-(ethoxycarbonyl)-1-methyl-vinyl]ureido}-benzoate with sodium isopropylate in isopropanol there is obtained isopropyl 2-chloro-4-fluoro-5-[3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate, m.p. 134°-136° C.,

Sources & evidence

ORD record
ord-2261aee3e2ff4257b78a0f9bd9eb3d8b
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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