Sodium → HCID 20130579, compound

HRID 845917Notes

Reaction equation

HRID 845917 reaction equation
[Br:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH:18][C:19]2[CH2:23][CH2:22][CH2:21][C:20]=2[C:24]([O:26]CC)=O)=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[Na]>C(O)(C)C>[Br:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:24](=[O:26])[C:20]3[CH2:21][CH2:22][CH2:23][C:19]=3[NH:18][C:16]2=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:8])[CH3:9])=[O:5]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 20130684HCID 20130684, compound

Product 1

HCID 20130579HCID 20130579, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

using isopropyl 2-bromo-4-fluoro-5-{3-[2-(ethoxycarbonyl)-1-cyclopenten-1-yl]ureido}-benzoate with sodium isopropylate in isopropanol there is obtained isopropyl 2-bromo-4-fluoro-5-(1,2,4,5,6,7-hexahydro-2,4-dioxo-3H-cyclopenta[d]pyrimidin-3-yl)-benzoate, m.p. 214°-216° C.,

Sources & evidence

ORD record
ord-63228921970b4d838bff8d12c4970dfa
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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