Dimethyl Sulfate → HCID 20130648, compound

HRID 845940Notes

Reaction equation

HRID 845940 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([C:22]#[N:23])=[CH:18][NH:17][C:16]2=[O:24])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].S(OC)(O[CH3:29])(=O)=O>CN(C)C=O>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([C:22]#[N:23])=[CH:18][N:17]([CH3:29])[C:16]2=[O:24])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 6497Dimethyl SulfateHCID 20130578HCID 20130578, compound

Product 1

HCID 20130648HCID 20130648, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

using isopropyl 2-chloro-4-fluoro-5-[5-cyano-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate and dimethyl sulphate in dimethylformamide there is obtained isopropyl 2-chloro-4-fluoro-5-[5-cyano-3,6-dihydro-3-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate, 1H--NMR (CDCl3, 400 MHz) 8.00 ppm (s, 1H), 7.83 ppm (d, 1H), 7.38 ppm (d, 1H), 5.25 ppm (m, 1H), 3.55 ppm (s, 3H), 1.37 ppm (2xd, 6H),

Sources & evidence

ORD record
ord-52de0326156c4eb287ff4cbc3498c753
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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