Butyric Acid → Formate

HRID 846043Notes

Reaction equation

HRID 846043 reaction equation
[C:1]([OH:5])(=[O:4])[CH2:2][OH:3].NCP(=O)(O)[OH:9].[C:12]([OH:17])(=[O:16])CCC.[C:18]([O-:22])(=[O:21])[CH2:19][OH:20]>>[C:1]([O-:5])(=[O:4])[CH:2]=[O:3].[CH:12]([O-:17])=[O:16].[C:19]([O-:9])(=[O:20])[C:18]([O-:22])=[O:21]

Participants

7

Reactant 4

HCID 264Butyric AcidHCID 757Glycolic AcidHCID 14017(Aminomethyl)phosphonic acidHCID 5460308Hydroxyacetate

Product 3

HCID 283FormateHCID 71081OxalateHCID 3614358Npc324351

Procedure

The reaction in Example 7 was repeated, using an aqueous solution containing glycolic acid (0.75M), aminomethylphosphonic acid (AMPA, 0.60M), FMN (0.01 mM), butyric acid (HPLC internal standard, 0.10M), glycolate oxidase (from spinach, 2.0 IU/mL), and catalase (from Aspergillus niger, 14,000 IU/mL) at pH 8.5.. After 40 h, the HPLC yields of glyoxylate, formate, and oxalate were 83.2%, 2.3%, and 7.5%, respectively, and no glycolate remained. The remaining activity of glycolate oxidase and catalase were 65% and 86%, respectively, of their initial values.

Workup

  1. customThe reaction in Example 7

Sources & evidence

ORD record
ord-0d16acaab32645f392b7fdd215a9b284
Source dataset
uspto-grants-1992_08
Patent number
US05135860

Reaction notes

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