HCID 14884394, compound → HCID 14884402, compound

HRID 846100Notes

Reaction equation

HRID 846100 reaction equation
C1(=O)[N:5]([CH2:6][CH2:7][CH2:8][S:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH2:19][CH2:20][C:21](=[O:24])[NH:22][N:23]=3)=[CH:14][CH:13]=2)(=[O:11])=[O:10])C(=O)C2=CC=CC=C12>C1(C)C=CC=CC=1.CN>[NH2:5][CH2:6][CH2:7][CH2:8][S:9]([C:12]1[CH:13]=[CH:14][C:15]([C:18]2[CH2:19][CH2:20][C:21](=[O:24])[NH:22][N:23]=2)=[CH:16][CH:17]=1)(=[O:10])=[O:11]

Participants

4

Reactant 1

HCID 14884394HCID 14884394, compound

Product 1

HCID 14884402HCID 14884402, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6329MethylamineSolvent

Procedure

30.0 g (70.7 mmol) of 6-[4-(3-phthalimidopropylsulphonyl)phenyl]-4,5-dihydro-3(2H)-pyridazinone are stirred vigorously for two hours at ambient temperature in a mixture of 200 ml of toluene and 300 ml of 40% aqueous methylamine solution. Then the solid matter precipitated is suction filtered, washed successively with 100 ml of water, 50 ml of acetone and 50 ml of diethylether and then dried over phosphorus pentoxide in a vacuum drying cupboard.

Workup

  1. customThen the solid matter precipitated
  2. filtrationfiltered
  3. washwashed successively with 100 ml of water, 50 ml of acetone and 50 ml of diethylether
  4. dry with materialdried over phosphorus pentoxide in a vacuum
  5. customdrying cupboard

Sources & evidence

ORD record
ord-911fc0b0f93246579ea76f66e4479c2b
Source dataset
uspto-grants-1992_08
Patent number
US05135932

Reaction notes

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