Hydrochloric Acid → HCID 888434, compound

HRID 846211Notes

Reaction equation

HRID 846211 reaction equation
[CH3:1][C:2]([C:5]1[CH:26]=[CH:25][C:8]([C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]([O:22]CC)=[O:21])=[CH:14][CH:13]=2)=[O:10])=[CH:7][CH:6]=1)([CH3:4])[CH3:3].[OH-].[Na+].Cl>>[CH3:4][C:2]([C:5]1[CH:26]=[CH:25][C:8]([C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]([OH:22])=[O:21])=[CH:14][CH:13]=2)=[O:10])=[CH:7][CH:6]=1)([CH3:1])[CH3:3]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14698592HCID 14698592, compound

Product 1

HCID 888434HCID 888434, compound

Procedure

2.0 g. 4-(1,1-Dimethylethyl)-N-[4-(ethoxycarbonylmethoxy)-phenyl]-benzamide (Example 31) are heated in 20 ml. 2N aqueous sodium hydroxide solution, then acidified with concentrated hydrochloric acid, filtered off with suction and washed with water. After recrystallisation from ethyl acetate, there is obtained 1.2 g. (65% of theory) of the title compound; m.p. 179°-181° C.

Workup

  1. filtrationfiltered off with suction
  2. washwashed with water
  3. customAfter recrystallisation from ethyl acetate
  4. customthere is obtained 1.2 g

Sources & evidence

ORD record
ord-7a544cf21af2493fbe2aa877bb2b26c5
Source dataset
uspto-grants-1992_08
Patent number
US05135949

Reaction notes

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