Hydrochloric Acid → HCID 13922800, compound

HRID 846241Notes

Reaction equation

HRID 846241 reaction equation
[Na].CN(C)C([S:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:20])[CH2:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])=[CH:9][CH:8]=1)=O.O.Cl>CO>[SH:6][C:7]1[CH:8]=[CH:9][C:10]([C:13](=[O:20])[CH2:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])=[CH:11][CH:12]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 5360545SodiumHCID 14211171HCID 14211171, compound

Product 1

HCID 13922800HCID 13922800, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sodium (280 mg, 12.18 mmoles) was dissolved in anhydrous methanol (50 ml). To the resulting solution was added the compound of Example 75, Step D (5.0 g). The mixture was stirred at room temperature for twelve hours and poured into a mixture of water (30 ml) and concentrated HCl (7 ml). The resulting yellow solid was collected by filtration, washed with water and dried to afford the title compound, m.p. 83°-84°.

Workup

  1. filtrationThe resulting yellow solid was collected by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-111db81f067a41d1b7da07209ede687c
Source dataset
uspto-grants-1992_08
Patent number
US05135940

Reaction notes

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