1,3-Dibromopropane → HCID 19884772, compound

HRID 846243Notes

Reaction equation

HRID 846243 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:16])[CH:9]([CH3:15])[CH2:10][C:11]([O:13][CH3:14])=[O:12])=[CH:4][CH:3]=1.[Br:17][CH2:18][CH2:19][CH2:20]Br.C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C>[Br:17][CH2:18][CH2:19][CH2:20][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:16])[CH:9]([CH3:15])[CH2:10][C:11]([O:13][CH3:14])=[O:12])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 80011,3-DibromopropaneHCID 11430Potassium CarbonateHCID 19884786HCID 19884786, compound

Product 1

HCID 19884772HCID 19884772, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

The mixture of the phenol from Step A (4.0 g) 1,3-dibromopropane (18.2 ml), potassium carbonate (7.5 g) and methyl ethyl ketone (100 ml) was refluxed for 1 hour. The mixture was filtered, concentrated in vacuo and the residue was purified by chromatography on silica gel to provide the title compound as an oil.

Workup

  1. temperaturewas refluxed for 1 hour
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated in vacuo
  4. customthe residue was purified by chromatography on silica gel

Sources & evidence

ORD record
ord-08d20a45b07a43ed96dc101a8850d5fb
Source dataset
uspto-grants-1992_08
Patent number
US05135940

Reaction notes

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