Sodium Iodide → 3-[4-[1-(2,3-Dimethylphenyl)-4-piperazinyl]butyl]-4-thiazolidinone hydrochloride

HRID 846412Notes

Reaction equation

HRID 846412 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:10](=[O:11])[CH2:9][S:8][CH2:7]1.[ClH:12].[CH3:13][C:14]1[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][C:15]=1[N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.C([O-])([O-])=O.[K+].[K+].[Na+].[I-]>CC#N>[ClH:12].[CH3:13][C:14]1[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][C:15]=1[N:21]1[CH2:22][CH2:23][N:24]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[C:10](=[O:11])[CH2:9][S:8][CH2:7]2)[CH2:25][CH2:26]1

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 108475053-(4-Bromobutyl)-4-thiazolidinoneHCID 130346471-(2,3-Dimethylphenyl)piperazine hydrochloride

Product 1

HCID 148561333-[4-[1-(2,3-Dimethylphenyl)-4-piperazinyl]butyl]-4-thiazolidinone hydrochloride

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 3-(4-bromobutyl)-4-thiazolidinone (4.0 g) and 1-(2,3-dimethylphenyl)piperazine hydrochloride (3.8 g) in 100 ml of anhydrous CH3CN were added K2CO3 (9.3 g) and NaI (200 mg). The mixture was heated to 80° with stirring under N2.

Workup

  1. temperatureThe mixture was heated to 80°

Sources & evidence

ORD record
ord-d3c35b11cfb94dd7b1c3d8f72c0150a2
Source dataset
uspto-grants-1992_08
Patent number
US05136037

Reaction notes

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