1-(2-Methoxyphenyl)piperazine → HCID 21706597, compound

HRID 846423Notes

Reaction equation

HRID 846423 reaction equation
[CH3:1][C:2]1([CH3:13])[N:6]([CH2:7][CH2:8][CH2:9][CH2:10][Cl:11])[C:5](=[O:12])[CH2:4][S:3]1.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1.C([O-])([O-])=O.[K+].[K+].[Na+].[I-]>CC#N>[OH2:12].[ClH:11].[CH3:1][C:2]1([CH3:13])[N:6]([CH2:7][CH2:8][CH2:9][CH2:10][N:25]2[CH2:24][CH2:23][N:22]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=3[O:15][CH3:14])[CH2:27][CH2:26]2)[C:5](=[O:12])[CH2:4][S:3]1

Participants

6

Reactant 4

HCID 13461-(2-Methoxyphenyl)piperazineHCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 21706621HCID 21706621, compound

Product 1

HCID 21706597HCID 21706597, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 2,2-dimethyl-3-(4-chlorobutyl)-4-thiazolidinone (3.26 g) and 1-(2-methoxyphenyl)piperazine (2.8 g) in 100 ml of anhydrous CH3CN were added anhydrous K2CO3 (4.5 g) and NaI (200 mg). The mixture was heated with stirring to 80° under N2.

Workup

  1. temperatureThe mixture was heated

Sources & evidence

ORD record
ord-dcaefff8799d419796885c6dedf1e90e
Source dataset
uspto-grants-1992_08
Patent number
US05136037

Reaction notes

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