反应详情

A mixture of 3-(4-bromobutyl)-2-methyl-1-thia-3-azaspiro[4.4]nonan-4-one (3.84 g), 1-(1,2-benzisothiazol-3-yl)piperazine hydrochloride (3.49 g), K2CO3 (5.90 g) and NaI (280 mg) in acetonitrile (215 ml) was heated at between 65°-80° C. for 16.5 hours and the product was processed in substantially the same manner as in Example 10 to afford 2.86 g of crystals, m.p. 210°-215° C.

1. temperaturewas heated at between 65°-80° C. for 16.5 hours