反应详情

温度

10 °C

Sodium hydride (6.0 g of 80% in oil) was added portionwise to a stirred solution of 4,6-dimethoxy-2-(methylsulphonyl)pyrimidine (21.8 g) and (3-chlorophenyl)acetonitrile (15.1 g) in dry dimethylformamide (150 ml) at 5° C. The mixture was stirred at 10° C. for 30 minutes, and then at room temperature for 3 hours. The resulting suspension was poured into water (1.2 l) and the oil was extracted into ether. The combined extracts were washed with saturated sodium chloride solution, dried over magnesium sulphate and evaporated to give an orange oil, which was purified by chromatography to give 26.3 g of the desired product as a pale yellow oil.

1. waitat room temperature for 3 hours
2. extractionthe oil was extracted into ether
3. washThe combined extracts were washed with saturated sodium chloride solution
4. dry with materialdried over magnesium sulphate
5. customevaporated
6. customto give an orange oil, which
7. customwas purified by chromatography