反应详情

Sodium hydride (0.83 g of 80% in oil) was added to a stirred solution of the product of Example 48 (8.0 g) in dimethylformamide at room temperature. Dimethyl sulphate (3.5 g) was then added, and the mixture was stirred at room temperature for 4 hours. The mixture was poured onto water (250 ml), and the oil was extracted into ethyl acetate. The combined extracts were dried over magnesium sulphate, and evaporated to give an orange liquid, which was purified by chromatography to give 5.2 g of the desired product as a white solid, mp 89°-93° C.

1. additionThe mixture was poured onto water (250 ml)
2. extractionthe oil was extracted into ethyl acetate
3. dry with materialThe combined extracts were dried over magnesium sulphate
4. customevaporated
5. customto give an orange liquid, which
6. customwas purified by chromatography