Triethylamine → HCID 19883104, compound

HRID 846588Notes

Reaction equation

HRID 846588 reaction equation
[N:1]1([S:7]([C:10]2[NH:11][C:12](=[O:16])[CH:13]=[CH:14][CH:15]=2)(=[O:9])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[S:17](Cl)([CH3:20])(=[O:19])=[O:18].C(N(CC)CC)C>ClCCl.C(Cl)(Cl)Cl>[N:1]1([S:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16][S:17]([CH3:20])(=[O:19])=[O:18])[N:11]=2)(=[O:9])=[O:8])[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 19883096HCID 19883096, compound

Product 1

HCID 19883104HCID 19883104, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 6344DichloromethaneSolvent2×

Procedure

A solution of the pyridone prepared in stage (v) (0.27 g) in dichoromethane (30 cm3) under nitrogen was cooled to 0° C. and a solution of mesyl chloride in chloroform was added (0.12 g in 5 cm3). The reaction mixture was stirred for 5 minutes then treated with triethylamine (0.1 g) in dichloromethane.

Sources & evidence

ORD record
ord-2eb8ac82c7904b64b2d7c744f74dc0f9
Source dataset
uspto-grants-1992_08
Patent number
US05137886

Reaction notes

Loading…