1-Iodopropane → HCID 86746070, compound

HRID 846823Notes

Reaction equation

HRID 846823 reaction equation
[ClH:1].Cl.[NH2:3][C:4]1[N:5]=[C:6]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[C:7]2[CH2:13][NH:12][CH2:11][CH2:10][C:8]=2[N:9]=1.I[CH2:22][CH2:23][CH3:24]>>[ClH:20].[ClH:1].[NH2:3][C:4]1[N:5]=[C:6]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[C:7]2[CH2:13][N:12]([CH2:22][CH2:23][CH3:24])[CH2:11][CH2:10][C:8]=2[N:9]=1

Participants

3

Reactant 2

HCID 336431-IodopropaneHCID 19883214HCID 19883214, compound

Product 1

HCID 86746070HCID 86746070, compoundYield 82.8%

Procedure

The title compound was prepared as described in Example 17 starting with 2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine dihydrochloride (4.0 g, 13.5 mmol) and iodopropane (1.3 mL, 13.5 mmol) instead of iodoethane to produce 2.1 g (51%) of 2-amino-4-(4-chlorophenyl)-6-propyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine dihydrochloride 1/4 hydrate. m.p. 244°-246° C. MS: 303(HM+).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-bf1a0287194846a18161523a1ed28df7
Source dataset
uspto-grants-1992_08
Patent number
US05137890

Reaction notes

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