Hydrogen Peroxide → 5-(2-carbamoyl-6,7-dihydropyrido[3,2-b]thieno[2,3-d]oxepin-9-yl)-1-(2,4-difluorophenyl)-1H-1,2,4-triazole

HRID 84683Notes

Reaction equation

HRID 84683 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:7][CH2:8][CH2:9][C:10]3[CH:16]=[C:15]([C:17]4[N:18]([C:22]5[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:23]=5[F:29])[N:19]=[CH:20][N:21]=4)[S:14][C:11]=3[C:12]=2[N:13]=1)#[N:2].OO.C(=O)([O-])[O-:33].[K+].[K+]>O.CS(C)=O>[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:7][CH2:8][CH2:9][C:10]3[CH:16]=[C:15]([C:17]4[N:18]([C:22]5[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:23]=5[F:29])[N:19]=[CH:20][N:21]=4)[S:14][C:11]=3[C:12]=2[N:13]=1)(=[O:33])[NH2:2]

Participants

6

Reactant 3

HCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 579005063-(2-cyano-6,7-dihydropyrido[3,2-b]thieno[2,3-d]oxepin-9-yl)-2-(2,4-difluorophenyl)-2H-1,2,4-triazole

Product 1

HCID 579005255-(2-carbamoyl-6,7-dihydropyrido[3,2-b]thieno[2,3-d]oxepin-9-yl)-1-(2,4-difluorophenyl)-1H-1,2,4-triazoleYield 38%

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Procedure

Following the procedure to prepare 379, compound 366, hydrogen peroxide, potassium carbonate in water and DMSO were reacted to give 432. Yield 38% MS: (ESI+)=426.1

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-0774f68763044af386a3455ab522a9f5
Source dataset
uspto-grants-2014_09
Patent number
US08846762B2

Reaction notes

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