Piperazine → 2-Methyl-4-(piperazin-1-yl)pyrimidine

HRID 846844Notes

Reaction equation

HRID 846844 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[N:3]=1.[NH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>O1CCCC1>[CH3:8][C:4]1[N:3]=[C:2]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:7]=[CH:6][N:5]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 4244474-Chloro-2-methylpyrimidine

Product 1

HCID 148385552-Methyl-4-(piperazin-1-yl)pyrimidine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

13 g of 4-chloro-2-methyl-pyrimidine were dissolved in 200 ml of tetrahydrofuran, and 17.5 g of piperazine were added. The reaction mixture was refluxed for 24 h. The precipitated piperazine hydrochloride was filtered off with suction and washed with tetrahydrofuran. Concentration of the solution in vacuo resulted in 19 g of 2-methyl-4-piperazino-pyrimidine, which was reacted without further purification.

Workup

  1. temperatureThe reaction mixture was refluxed for 24 h
  2. filtrationThe precipitated piperazine hydrochloride was filtered off with suction
  3. washwashed with tetrahydrofuran
  4. customConcentration of the solution in vacuo resulted in 19 g of 2-methyl-4-piperazino-pyrimidine
  5. customwhich was reacted without further purification

Sources & evidence

ORD record
ord-1684b2b7aac043178849f16e01f9be81
Source dataset
uspto-grants-1992_08
Patent number
US05138058

Reaction notes

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