Phthalimide → 2-Tert-butyoxycarbonylamino-3-octadecylcarbonyloxypropylamine

HRID 846984Notes

Reaction equation

HRID 846984 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]([CH2:11][O:12][C:13](=[O:33])NCCCCCCCCCCCCCCCCCC)[CH3:10])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(SCC(OC)C[NH2:54])CCCCCCCCCCCCCCC.C1(=O)NC(=O)C2=CC=CC=C12.CNC(OC(COC(=O)N[CH2:80][CH2:81][CH2:82][CH2:83][CH2:84][CH2:85][CH2:86][CH2:87][CH2:88][CH2:89][CH2:90][CH2:91][CH2:92][CH2:93][CH2:94][CH2:95][CH2:96][CH3:97])CN)=O>>[C:1]([O:5][C:6]([NH:8][CH:9]([CH2:11][O:12][C:13]([CH2:80][CH2:81][CH2:82][CH2:83][CH2:84][CH2:85][CH2:86][CH2:87][CH2:88][CH2:89][CH2:90][CH2:91][CH2:92][CH2:93][CH2:94][CH2:95][CH2:96][CH3:97])=[O:33])[CH2:10][NH2:54])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

5

Reactant 4

HCID 6809PhthalimideHCID 148349992-Methylcarbamoyloxy-3-octadecylcarbamoyloxypropylamineHCID 149922653-Hexadecylthio-2-methoxypropylamineHCID 198842262-tert-Butoxycarbonylamino-3-octadecylcarbamoyloxypropane

Product 1

HCID 1317174902-Tert-butyoxycarbonylamino-3-octadecylcarbonyloxypropylamine

Procedure

2-tert-Butoxycarbonylamino-3-octadecylcarbamoyloxypropane V e2 is allowed to react and worked up by the same procedure as described in (3). The phthalimide compound: m.p. 127°-129° C., The amino compound IV e2 69°-70° C. The summary of the experimental condition and the physical data of the product are listed in Tables 5 and 6.

Workup

  1. customto react

Sources & evidence

ORD record
ord-73ae356a95f04ec99243e7972d7dbca4
Source dataset
uspto-grants-1992_08
Patent number
US05138067

Reaction notes

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