Trifluoroacetic acid → HCID 19966764, compound

HRID 847126Notes

Reaction equation

HRID 847126 reaction equation
C([NH:5][S:6]([C:9]1[C:14]([NH:15][CH3:16])=[CH:13][CH:12]=[CH:11][N:10]=1)(=[O:8])=[O:7])(C)(C)C.FC(F)(F)C(O)=O.C(OCC)(=O)C>CCCCCC>[CH3:16][NH:15][C:14]1[C:9]([S:6]([NH2:5])(=[O:8])=[O:7])=[N:10][CH:11]=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 8857Ethyl AcetateHCID 19881833HCID 19881833, compound

Product 1

HCID 19966764HCID 19966764, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

A mixture of 3.50 g of N-tert-butyl-3-methylamino-2-pyridinesulfonamide and 20 ml of trifluoroacetic acid was reacted at about 50° C. for 2 hours. Thereafter, the reaction product was distilled off under a reduced pressure to obtain a residue. Ethyl acetate and n-hexane were added thereto. The resulting crystals were filtered to obtain 2.41 g of 3-methylamino 2-pyridinesulfonamide. This compound had the following NMR values.

Workup

  1. customwas reacted at about 50° C. for 2 hours
  2. distillationThereafter, the reaction product was distilled off under a reduced pressure
  3. customto obtain a residue
  4. filtrationThe resulting crystals were filtered

Sources & evidence

ORD record
ord-70303c2ff47d4d3e83d7f3f9bb529c85
Source dataset
uspto-grants-1992_08
Patent number
US05139565

Reaction notes

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