Triethylamine → Ethyl 4-[2-(4-cyanobenzenesulphonylamino)-ethyl]-cyclohexylacetate

HRID 847227Notes

Reaction equation

HRID 847227 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1)#[N:2].Cl.[NH2:14][CH2:15][CH2:16][CH:17]1[CH2:22][CH2:21][CH:20]([CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH2:19][CH2:18]1.C(N(CC)CC)C>C(Cl)Cl>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH:14][CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][CH:20]([CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH2:19][CH2:18]2)(=[O:11])=[O:10])=[CH:5][CH:4]=1)#[N:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 394974-Cyanobenzenesulfonyl chlorideHCID 67807757HCID 67807757, compound

Product 1

HCID 20078478Ethyl 4-[2-(4-cyanobenzenesulphonylamino)-ethyl]-cyclohexylacetateYield 95%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

by the reaction of 4-cyanobenzenesulphonyl chloride with ethyl 4-(2-aminoethyl)-cyclohexylacetate hydrochloride in methylene chloride in the presence of triethylamine. Yield 95% of theory, colourless oil.

Sources & evidence

ORD record
ord-8d76213fc8a14a64962dae70317a9d1a
Source dataset
uspto-grants-1992_08
Patent number
US05140038

Reaction notes

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