Acetone → HCID 22706905, compound

HRID 847243Notes

Reaction equation

HRID 847243 reaction equation
[CH2:1]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=O)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[C:13]1([NH2:20])[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[NH2:19].S([O-])([O-])=O.[Na+].[Na+].CC(C)=O>O>[CH2:1]([C:5]1[CH:12]=[CH:11][C:8]([C:9]2[NH:19][C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[N:20]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

6

Reactant 4

HCID 180AcetoneHCID 7243O-PhenylenediamineHCID 24437Sodium SulfiteHCID 709884-Butylbenzaldehyde

Product 1

HCID 22706905HCID 22706905, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Into a four-necked flask of 1 l capacity were charged 40.5 g (0.25 mol) of p-n-butylbenzaldehyde, 27.0 g (0.25 mol) of o-phenylenediamine, 28.6 g (0.23 mol) of sodium sulfite and 350 ml of dimethylformaldehyde, and a reaction was effected for 1 hour while refluxing the reaction solution. Then, 250 ml of water was added to the reaction mass, and the resulting mixture was cooled and filtered. The filter cake was washed with water to obtain the aimed 2-p-n-butylphenylbenzimidazole in an yield of 52.2 g (82.9%).

Workup

  1. temperaturewhile refluxing the reaction solution
  2. temperaturethe resulting mixture was cooled
  3. filtrationfiltered
  4. washThe filter cake was washed with water

Sources & evidence

ORD record
ord-6c6c79134456492d9100c604ed16ce98
Source dataset
uspto-grants-1992_08
Patent number
US05140055

Reaction notes

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