HCID 67916069, compound → HCID 136403387, compound

HRID 847365Notes

Reaction equation

HRID 847365 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:12]=[CH:13][C:14]=1[C:15]1[NH:19][N:18]=[CH:17][C:16]=1[CH:20]([CH3:25])[C:21]([NH:23][NH2:24])=[O:22])C1C=CC=CC=1>C(O)(C)C.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH:12]=[CH:13][C:14]=1[C:15]1[NH:19][N:18]=[CH:17][C:16]=1[CH:20]([CH3:25])[C:21]([NH:23][NH2:24])=[O:22]

Participants

4

Reactant 1

HCID 67916069HCID 67916069, compound

Product 1

HCID 136403387HCID 136403387, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 3776IsopropanolSolvent

Procedure

3 g of 5-(3-benzyloxy-1,1'-biphenyl-4-yl)-1H-pyrazol-4-yl-propionic acid hydrazide are dissolved with heating in isopropanol and hydrogenated over 10% palladium/charcoal. The catalyst is filtered off, the reaction mixture concentrated by evaporation and the concentrate allowed to stand for ca. 12 hrs. in a refrigerator. The title compound crystallises out as the dihydrochloride and is recovered by filtration: m.p.=138°-141° C.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe reaction mixture concentrated by evaporation
  3. customThe title compound crystallises out as the dihydrochloride
  4. filtrationis recovered by filtration

Sources & evidence

ORD record
ord-0295571eae5444bdaac84e146dd23e08
Source dataset
uspto-grants-1992_08
Patent number
US05141951

Reaction notes

Loading…