Hydrochloric Acid → HCID 9887011, compound

HRID 847403Notes

Reaction equation

HRID 847403 reaction equation
[CH2:1]([Se:8][C:9]1[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[CH:14][C:10]=1[C:11](Cl)=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.Cl>N1C=CC=CC=1>[CH2:1]([Se:8][C:9]1[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[CH:14][C:10]=1[C:11]([NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6115AnilineHCID 19881378HCID 19881378, compound

Product 1

HCID 9887011HCID 9887011, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 1.37 g (0.0041 mol) 2-benzylseleno-3-methoxybenzoyl chloride (prepared from 2-benzylseleno-3-methoxybenzoic acid and α,α-dichloromethyl ether in dichloromethane at room temperature) in 10 ml pyridine at 0° C. is added with stirring a solution of 0.38 g (0.0041 mol-0.37 ml) aniline. After stirring at room temperature for 18 hours the contents of the flask are poured onto 150 g ice and 50 ml 25% HCl and extracted. The organic phase is washed with 50 ml 10% NaHCO3 and twice with 100 ml portions of dichloromethane and 200 ml water, dried over sodium sulfate and the solvent removed in vacuum.

Workup

  1. extractionextracted
  2. washThe organic phase is washed with 50 ml 10% NaHCO3 and twice with 100 ml portions of dichloromethane and 200 ml water
  3. dry with materialdried over sodium sulfate
  4. customthe solvent removed in vacuum

Sources & evidence

ORD record
ord-ef2bc602889841ccb55f5716d601a743
Source dataset
uspto-grants-1992_08
Patent number
US05141955

Reaction notes

Loading…